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The three key competitive advantages of the unified Kalyspo system is low cost, thorough validation, and the detection of retained surgical instruments (RSIs) that no other technology can account for.

Barcoding and Radio Frequency (RF) technologies rely on proprietary read-out devices. Their cost is either built into higher priced surgical consumables or has to be paid upfront. For a hospital with 25 operating rooms this translates to almost half a million in upfront cost. Kalyspo uses portable x-ray machines that are already present in every hospital and the hospital can bill for the portable radiograph. A hospital can have the value of a safety technology at minimal cost.

The detection accuracy of the Kalyspo Computer Aided Detection (CAD) technology is validated on thousands of cadaver images. This cannot be done with barcoding or RF technologies that need to be prospectively evaluated on millions of surgeries to gain statistical significance. The Kalyspo CAD can detect needles and other x-ray visible objects which comprise a third of RSIs and no other technology can account for.